Quinine, one of the older treatments for malaria, is not without side-effects. Research now shows that a source for these problems may be quinine's ability to reduce intake of tryptophan. Without this essential amino acid, humans are unable to make new proteins in the numbers needed for optimal health and growth.
There are 6000 genes in yeasts. Researchers have made mutant yeast clones - each one lacking one of these 6000 genes. This research was done using the complete genetic library of clones. They were able to show that two of these strains, both of which were unable to make tryptophan transporters had diminished growth.
To read the article summary, go to: <http://www.eurekalert.org/pub releases/2009-06/asfb-tdm0609.php>.
The complete article will appear in the July 3rd issue of Journal of Biological Chemistry.